Topical retinoids found to help reduce inflammatory and pigmentary skin conditions

Topical retinoids have been the cornerstone of acne treatment for decades, and recently, these medications have been researched for their usefulness for other inflammatory and pigmentary skin conditions, particularly for acanthosis nigricans (AN).

AN is a condition that causes areas of dark, thick velvety skin in body folds and creases. This pigmentary skin condition is often a point of concern for those with the condition, affecting their quality of life due to the stark pigmentation of the skin.

A recent study across an 8-week trial assessed the efficacy and safety profiles of the different strengths of tretinoin creams in managing AN neck lesions at levels of 0.025% and 0.05%.

The study from Treesirichod et al revealed there was no difference in reduction of pigmentation between the 2 concentrations and both strengths reported an average of 20% improvement.

Patients using 0.025% did not experience any irritation; however, those using 0.05% tretinoin reported mild to moderate skin irritation.

All About Acne expert, Dr JoAnn See, suggests that while this study found that topical retinoids provide a great result in treating inflammatory and pigmentary skin conditions, assessing the long-term efficacy, safety profile, and compliance of this study is needed.

Dr See also encourages healthcare providers to talk openly with patients on different treatment options available and explore what works best for each person— treatment plans work best when individualised.

Reference: Arch Dermatol Res 2023;315(4):963-70.